. A practical study of malaria. ularly. It is regardedas a result of prolonged hemoglobinemia following severe orchronic infections. The general plan of distribution of melanin may be thusstated: In the blood current it may exist free or, more com-monly, is contained within the phagocytes and the red cellsinfected with pigmented parasites, and is more abundant inthe capillaries than in the larger vessels. In the viscera it isoftenest seen in the spleen, bone-marrow, brain, and liver,especially in the endothelial cells, but in the spleen and bone-marrow it exists also outside the vessels and ei
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. A practical study of malaria. ularly. It is regardedas a result of prolonged hemoglobinemia following severe orchronic infections. The general plan of distribution of melanin may be thusstated: In the blood current it may exist free or, more com-monly, is contained within the phagocytes and the red cellsinfected with pigmented parasites, and is more abundant inthe capillaries than in the larger vessels. In the viscera it isoftenest seen in the spleen, bone-marrow, brain, and liver, especially in the endothelial cells, but in the spleen and bone-marrow it exists also outside the vessels and either betweenor within the cells proper to these tissues. The distribution of the parasites varies according to thetype of the attack; it has been shown that the latter dependslargely upon the localizations of the parasites. They are usu-ally abundant in the splenic blood irrespective of the formassumed by the attack. It occasionally happens that deathsupervenes, notwithstanding a progressive diminution of the 174 PLATE VI 9 - |. Fig. i. FiV. 2. lew w^