HRT,Hormone Replacement Therapy, menopause treatment gel,estradiol,transdermal,shortages. Orion Pharma in UK England
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England, UKMore information:
File under Oestrogel, Ovestin, cream, Premique, NHS, pharmacist Percutaneous estradiol gel can be prescribed at low doses. Relief of menopausal symptoms can begin as early as 2 weeks after starting treatment Treatment with estradiol gel maintains or increases bone mineral density. No large randomized, controlled trials have explored the effect of estradiol gel on coronary artery disease. It appears to have metabolic effects similar to those of oral estradiol Because percutaneous estradiol stimulates the endometrium, women with an intact uterus should also take a progestogen Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. These symptoms can include hot flashes, vaginal atrophy, accelerated skin aging, vaginal dryness, decreased muscle mass, sexual dysfunction, and bone loss. They are in large part related to the diminished levels of sex hormones that occur during menopause. Estrogens and progestogens are the main hormone drugs used in HRT. Progesterone is the main female sex hormone that occurs naturally and is also manufactured into a drug that is used in menopausal hormone therapy. Although both classes of hormones can have symptomatic benefit, progestogen is specifically added to estrogen regimens when the uterus is present to avoid the increased risk of endometrial cancer. Unopposed estrogen therapy promotes endometrial hyperplasia and increases the risk of cancer, while progestogen reduces this risk. Androgens like testosterone are sometimes used as well. HRT is available through a variety of different routes. The long-term effects of HRT on most organ systems vary by age and time since the last physiological exposure to hormones, and there can be large differences in individual regimens, factors which have made analyzing effects difficult